Article

Unveiling Key Immune Genes and Drug Candidates for Krabbe Disease in Human iPSCs-derived NSCs

2024-12-19

Abstract excerpt

<title>Abstract</title> <p>Globoid cell leukodystrophy (GLD), also known as Krabbe disease, is a rare genetic neurodegenerative disorder caused by deficiency of the lysosomal enzyme GALC. Abnormal cytokine expression in the immune system of GLD patients potentially contributes to immune imbalances crucial in disease pathogenesis. This study aimed to identify key immune genes and potential drug candidates related...

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Literature Corpus work: b624b776-18ab-54db-a1d4-19687ca87bf0
DOI: 10.21203/rs.3.rs-5377355/v1

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