Article

Linear epitope landscape of SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients

2020-07-14

Abstract excerpt

Neutralization antibodies and vaccines for treating COVID-19 are desperately needed. For precise development of antibodies and vaccines, the key is to understand which part of SARS-CoV-2 Spike protein is highly immunogenic on a systematic way. We generate a linear epitope landscape of Spike protein by analyzing serum IgG response of 1,051 COVID-19 patients with a peptide microarray. We reveal two regions that rich...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e6468e3a-5d1d-568a-8c41-f220100cf40a
DOI: 10.1101/2020.07.13.20152587

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Linear epitope landscape of SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patientsDOI 10.1101/2020.07.13.20152587Read

Linear Epitope Landscape of SARS-CoV-2 Spike Protein Constructed from 1,051 COVID-19 PatientsSemantic proximity Read

Linear epitope landscape of the SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patientsSemantic proximity Read

Identification of three conserved linear B cell epitopes on the SARS-CoV-2 spike proteinSemantic proximity Read

Vaccine design based on 16 epitopes of SARS‐CoV‐2 spike proteinSemantic proximity Read

The influence of major S protein mutations of SARS-CoV-2 on the potential B cell epitopesSemantic proximity Read

Identification of a promiscuous conserved CTL epitope within the SARS-CoV-2 spike proteinSemantic proximity Read

Designing a novel vaccine against COVID-19 based on spike SARS-Cov-2 notable mutations using immunoinformatics approaches.Semantic proximity Read

SARS-CoV-2 mutations and where to find them: An <i>in silico</i> perspective of structural changes and antigenicity of the Spike proteinSemantic proximity Read

Identification of a Promiscuous Conserved CTL Epitope Within the SARS-CoV-2 Spike ProteinSemantic proximity Read

Omicron-included mutation-induced changes in epitopes of SARS-CoV-2 spike protein and effectiveness assessments of current antibodiesSemantic proximity Read

Dynamics prediction of emerging notable spike protein mutations in SARS-CoV-2 implies a need for updated vaccines.Semantic proximity Read

Spike Proteins of SARS –CoV-2: a detailed perspective on structure, receptor binding, antigenicity, vaccine development and neutralizationSemantic proximity Read