Article

Decorin Promotes Nascent Proteoglycan Retention in Cartilage Matrix by Strengthening Collagen II-Aggrecan Integration

2025-11-13

Abstract excerpt

Cartilage extracellular matrix (ECM), a hydrated collagen II-aggrecan composite, undergoes dynamic turnover during both normal homeostasis and disease-associated remodeling. This study elucidates a crucial role for decorin in promoting the retention and stability of nascent aggrecan within this matrix. By applying bio-orthogonal click-labeling, we demonstrate that loss of decorin accelerates the release of nascent...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b5bbaae4-7da5-558a-81d4-75d499387e5c
DOI: 10.1101/2025.11.12.688145

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Decorin Promotes Nascent Proteoglycan Retention in Cartilage Matrix by Strengthening Collagen II-Aggrecan IntegrationDOI 10.1101/2025.11.12.688145Read

Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biologySemantic proximity Read

Investigating the temporal roles of decorin and biglycan in tendon healingSemantic proximity Read

Role of Decorin in the Lens and Ocular DiseasesSemantic proximity Read

Rejuvenating Hyaline Cartilaginous Phenotype of Dedifferentiated Chondrocytes in Collagen II Scaffolds: A Mechanism Study Using Chondrocyte Membrane Nanoaggregates as Antagonists.Semantic proximity Read

The role of decorin in collagen fibrillogenesis and skin homeostasis.Semantic proximity Read

Decorin: a multifunctional proteoglycan involved in oocyte maturation and trophoblast migrationSemantic proximity Read

Differential interactions of decorin and decorin mutants with type I and type VI collagens.Semantic proximity Read

Controlled decorin delivery from injectable microgels promotes scarless vocal fold repairSemantic proximity Read

The glycosaminoglycan chain of decorin plays an important role in collagen fibril formation at the early stages of fibrillogenesis.Semantic proximity Read

Local delivery of decorin via hyaluronic acid microrods improves cardiac performance and ventricular remodeling after myocardial infarction.Semantic proximity Read

The elusive functions of proteoglycans: in vivo veritas.Semantic proximity Read

A central role for decorin during vertebrate convergent extension.Semantic proximity Read