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Article

The glycosaminoglycan chain of decorin plays an important role in collagen fibril formation at the early stages of fibrillogenesis.

The FEBS journal - 1 Aug 2007

Rühland Claus, Schönherr Elke, Robenek Horst, Hansen Uwe, Iozzo Renato V, Bruckner Peter, Seidler Daniela G

Abstract excerpt

Decorin is a multifunctional small leucine-rich proteoglycan involved in the regulation of collagen fibrillogenesis. In patients with a variant of Ehlers-Danlos syndrome, about half of the secreted decorin lacks the single glycosaminoglycan side chain. Notably, these patients have a skin-fragility phenotype that resembles that of decorin null mice. In this study, we investigated the role of glycanated and...

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Identifiers

PMID: 17651433
DOI: 10.1111/j.1742-4658.2007.05951.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The glycosaminoglycan chain of decorin plays an important role in collagen fibril formation at the early stages of fibrillogenesis.PMID 17651433Read ↗

The role of decorin in collagen fibrillogenesis and skin homeostasis.Semantic proximity Read ↗

Deficiency of the decorin core protein in the variant form of Ehlers-Danlos syndrome with chronic skin ulcer.Semantic proximity Read ↗

Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and mimic Ehlers-Danlos-like changes in bone and other connective tissues.Semantic proximity Read ↗

A physiologic three-dimensional cell culture system to investigate the role of decorin in matrix organisation and cell survival.Semantic proximity Read ↗

Decorin counteracts disease progression in mice with recessive dystrophic epidermolysis bullosaSemantic proximity Read ↗

Differential interactions of decorin and decorin mutants with type I and type VI collagens.Semantic proximity Read ↗

Decorin Promotes Nascent Proteoglycan Retention in Cartilage Matrix by Strengthening Collagen II-Aggrecan IntegrationSemantic proximity Read ↗

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Structure of the Fibrillin-1 N-Terminal Domains Suggests that Heparan Sulfate Regulates the Early Stages of Microfibril AssemblySemantic proximity Read ↗

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