Article

Induction of cross-reactive antibody responses against the RBD domain of the spike protein of SARS-CoV-2 by commensal microbiota

2021-08-08

Abstract excerpt

The commensal microflora is a source for multiple antigens that may induce cross-reactive antibodies against host proteins and pathogens. However, whether commensal bacteria can induce cross-reactive antibodies against SARS-CoV-2 remains unknown. Here we report that several commensal bacteria contribute to the generation of cross-reactive IgA antibodies against the receptor-binding domain (RBD) of the SARS-CoV-2 S...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b5a4441c-a4db-5944-846c-288c49910c82
DOI: 10.1101/2021.08.08.455272

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Induction of cross-reactive antibody responses against the RBD domain of the spike protein of SARS-CoV-2 by commensal microbiotaDOI 10.1101/2021.08.08.455272Read

A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction.Semantic proximity Read

Preexisting antibodies targeting SARS-CoV-2 S2 cross-react with commensal gut bacteria and impact COVID-19 vaccine induced immunitySemantic proximity Read

Cross-reactivity of antibodies from non-hospitalized COVID-19 positive individuals against the native and B.1.351 SARS-CoV-2 spike proteinsSemantic proximity Read

Cross-reactive antibodies elicited to conserved epitopes on SARS-CoV-2 spike protein after infection and vaccinationSemantic proximity Read

Pre-existing antibodies targeting a linear epitope on SARS-CoV-2 S2 cross-reacted with commensal gut bacteria and shaped vaccine induced immunitySemantic proximity Read

Immunoglobulin a Response to Sars-Cov-2 Infection and ImmunitySemantic proximity Read

The secretory IgA (sIgA) response in human milk against the SARS-CoV-2 Spike is highly durable and neutralizing for at least 1 year of lactation post-infectionSemantic proximity Read

Cross-Reactivity of SARS-CoV Structural Protein Antibodies Against SARS-CoV-2Semantic proximity Read

High microbiota reactivity of adult human intestinal IgA requires somatic mutations.Semantic proximity Read

Human IgA binds a diverse array of commensal bacteriaSemantic proximity Read

Distinct systemic and gut IgA responses to bacteria of the human upper gastrointestinal tractSemantic proximity Read

Long-term systemic and mucosal SARS-CoV-2 IgA response and its association with persistent smell and taste disordersSemantic proximity Read