A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction.

doi:10.1038/s41467-020-18058-8

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Article

A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction.

Nature communications - 21 Aug 2020

Ejemel Monir, Li Qi, Hou Shurong, Schiller Zachary A, Tree Julia A, Wallace Aaron, Amcheslavsky Alla, Kurt Yilmaz Nese, Buttigieg Karen R, Elmore Michael J, Godwin Kerry, Coombes Naomi, Toomey Jacqueline R, Schneider Ryan, Ramchetty Anudeep S, Close Brianna J, Chen Da-Yuan, Conway Hasahn L, Saeed Mohsan, Ganesa Chandrashekar, Carroll Miles W, Cavacini Lisa A, Klempner Mark S, Schiffer Celia A, Wang Yang

Abstract excerpt

COVID-19 caused by SARS-CoV-2 has become a global pandemic requiring the development of interventions for the prevention or treatment to curtail mortality and morbidity. No vaccine to boost mucosal immunity, or as a therapeutic, has yet been developed to SARS-CoV-2. In this study, we discover and characterize a cross-reactive human IgA monoclonal antibody, MAb362. MAb362 binds to both SARS-CoV and SARS-CoV-2...

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Identifiers

PMID: 32826914
DOI: 10.1038/s41467-020-18058-8
PMCID: PMC7442812

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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