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Creatine and L-carnitine attenuate muscular laminopathy in the LMNA mutation transgenic zebrafish

2023-10-24

Abstract excerpt

LMNA gene mutations cause debilitating striated muscle laminopathies, affecting cardiac and skeletal muscles, with limited treatments. This study investigates five LMNA mutations using zebrafish models. Transgenic zebrafish expressing wild-type LMNA and each mutation are extensively profiled for morphology, behavior, and histology, with a focus on skeletal muscles. Drug screening and transcriptomic analysis uncove...

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Identifiers and source

Literature Corpus work
cf52711a-404a-5cbb-8331-e071f6b52b69
DOI
10.21203/rs.3.rs-3459957/v1
Open publication

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Creatine and L-carnitine attenuate muscular laminopathy in the LMNA mutation transgenic zebrafishDOI 10.21203/rs.3.rs-3459957/v1
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