Article

Leveraging the Human Panproteome to Enhance Peptide and Protein Identification in Proteomics and Metaproteomics

2024-11-26

Abstract excerpt

In this paper, we developed a novel approach to utilize the human pangenome to improve peptide and protein identification from proteomic data (MS/MS spectra). We propose a new data structure called panproteome graph (PPG), in which nodes are tryptic peptides, to represent the human pangenome. The PPG can be built in linear time and can be utilized via graph traversal using a depth-first search algorithm to generat...

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Literature Corpus work: b557f9fd-915b-5533-91b0-1d845765b5ac
DOI: 10.1101/2024.11.25.625239

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