Article

MetaPilot: genome-aware adaptive search-space refinement for unified DDA and DIA metaproteomics

2026-06-16

Abstract excerpt

Metaproteomic peptide identification is constrained by the structure and size of the protein search space. Pooled gene catalogues provide coverage but obscure genome-level evidence, and current workflows for data-dependent (DDA) and data-independent (DIA) acquisition diverge in their database strategies. We present MetaPilot, a genome-aware software platform that uses conserved marker-protein evidence to rank cand...

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Literature Corpus work: 909710c8-5146-5362-931d-16a573406ecc
DOI: 10.64898/2026.06.12.728088

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