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Class switch toward IgG2 and IgG4 is more pronounced in BNT162b2 compared to mRNA-1273 COVID-19 vaccinees

17 Jul 2025

Abstract excerpt

OBJECTIVES: Vaccination against SARS-CoV-2 induces antibodies that reduce the risk of severe disease. Because IgG subclasses differ in their ability to activate complement, to bind Fc receptors and neutralize viruses, it is crucial to understand how IgG subclass responses differ between vaccine platforms. DESIGN: IgG1, IgG2, IgG3, and IgG4 binding antibodies against SARS-CoV-2 trimeric spike protein,...

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PMID: 40681092
DOI: 10.1016/j.ijid.2025.107990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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