Article

RUNX1 controls the dynamics of cell cycle entry of naïve resting B cells by regulating expression of cell cycle and immunomodulatory genes in response to BCR stimulation

2020-12-02

Abstract excerpt

<h4>ABSTRACT</h4> RUNX1 is a transcription factor that plays key roles in haematopoietic development and in adult haematopoiesis and lymphopoiesis. Here we report that RUNX1 is also involved in controlling the dynamics of cell cycle entry of naïve resting B cells in response to stimulation of the B cell receptor (BCR). Conditional knockout of Runx1 in mouse resting B cells resulted in accelerated entry of the ce...

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Literature Corpus work: b5167388-a6ba-51e0-ab06-577b4c1ca367
DOI: 10.1101/2020.12.01.406744

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