Article

Deep-learning-derived glaucoma-related endophenotypes enable novel genome-wide genetic and functional discovery

2026-01-22

Abstract excerpt

<title>Abstract</title> <p>The genetic architecture of primary open-angle glaucoma (POAG), a leading cause of irreversible blindness, remains largely unexplained due to the reliance of previous genome-wide association studies (GWAS) on imprecise phenotypes from electronic health records. Here, we overcome this with a disease-trained, task-transfer machine learning (ML) framework that learns glaucoma-related damag...

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Literature Corpus work: b48fc2c6-4bd2-5765-9846-43cbec6c25d9
DOI: 10.21203/rs.3.rs-8311177/v1

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