Article

Sex-specific and age-related progression of auditory neurophysiological deficits in the <i>Cln3</i> mouse model of Batten disease

2025-03-18

Abstract excerpt

CLN3 disease is a prevalent form of Neuronal Ceroid Lipofuscinosis (NCL) caused by inherited mutations in the CLN3 gene, with symptoms such as vision loss, language impairment, and cognitive decline. The early onset of visual deficits complicates neurological assessment of brain pathophysiology underlying cognitive decline, while the small number of CLN3 mutation cases in humans hinders the study of sex differen...

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Literature Corpus work: b461639f-ca65-50f6-9c31-1a59980541a0
DOI: 10.1101/2025.03.18.643722

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