Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thymoquinone Enhances Apoptosis of K562 Chronic Myeloid Leukemia Cells through Hypomethylation of SHP-1 and Inhibition of JAK/STAT Signaling Pathway

15 Jun 2023

Abstract excerpt

The epigenetic silencing of tumor suppressor genes (TSGs) is critical in the development of chronic myeloid leukemia (CML). SHP-1 functions as a TSG and negatively regulates JAK/STAT signaling. Enhancement of SHP-1 expression by demethylation provides molecular targets for the treatment of various cancers. Thymoquinone (TQ), a constituent of Nigella sativa seeds, has shown anti-cancer activities in various...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Liver Diseases and Immunity
Share to Retinoids in leukemia and cellular processes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37375831
DOI: 10.3390/ph16060884

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thymoquinone Enhances Apoptosis of K562 Chronic Myeloid Leukemia Cells through Hypomethylation of SHP-1 and Inhibition of JAK/STAT Signaling PathwayPMID 37375831Read ↗

Homoharringtonine exhibits potent anti-tumor effect and modulates DNA epigenome in acute myeloid leukemia by targeting SP1/TET1/5hmCSemantic proximity Read ↗

Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeuticsSemantic proximity Read ↗

Therapeutic Implications of Black Seed and Its Constituent Thymoquinone in the Prevention of Cancer through Inactivation and Activation of Molecular PathwaysSemantic proximity Read ↗

Wee1 promotes cell proliferation and imatinib resistance in chronic myeloid leukemia via regulating DNA damage repair dependent on ATM-γH2AX-MDC1Semantic proximity Read ↗

Targeting microRNAs with thymoquinone: a new approach for cancer therapySemantic proximity Read ↗

Chidamide: Targeting epigenetic regulation in the treatment of hematological malignancySemantic proximity Read ↗

Bromodomain and extra-terminal (BET) inhibitors in treating myeloid neoplasmsSemantic proximity Read ↗

Consideration of SHP-1 as a Molecular Target for Tumor TherapySemantic proximity Read ↗

Promising Anti-leukemic Effect of Zataria Multiflora Extract in Combination with Doxorubicin to Combat Acute Lymphoblastic Leukemia Cells (Nalm-6)Semantic proximity Read ↗

Inhibition of TERT suppressed proliferation and induced apoptosis in chronic myeloid leukemia cellsSemantic proximity Read ↗

Aberrant Hydroxymethylation In Promoter Cpg Regions of Genes Related to the Cell Cycle and Apoptosis Characterizes Advanced Chronic Myeloid Leukemia Disease, Poor Imatinib Respondents And Poor Survival.Semantic proximity Read ↗

Deciphering the Dose-Dependent Effects of Thymoquinone on Transcriptomic Changes and Cellular Proliferation in GlioblastomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.