Article

Causal Inference in Non-Allergic Asthma Associated with Obesity: Application of the Bradford Hill Viewpoints to a Complex Epidemiological Association

2026-06-05

Abstract excerpt

The association between obesity and a distinct, non-allergic, late-onset, neutrophilic asthma phenotype has been recognised for over two decades. However, establishing obesity as a causal factor rather than a comorbidity remains methodologically chal-lenging. Randomised allocation to obesity is neither feasible nor ethical. The relationship is mediated by a complex network of mechanical, immunometabolic, microbial...

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Literature Corpus work: b434ba96-aa7b-53c8-956a-7e03afe4ff28
DOI: 10.20944/preprints202606.0451.v1

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