Article
Mutations in folP associated with elevated sulfonamide MICs for Neisseria meningitidis clinical isolates from five continents.
Antimicrobial agents and chemotherapy - 1 Feb 2005
Fiebelkorn K R, Crawford S A, Jorgensen J H
Abstract excerpt
Sulfonamide resistance in meningococci is associated with mutations in the chromosomal gene folP, which encodes dihydropteroate synthase. Several mutations associated with resistance have been previously described, including amino acid substitutions at codons 31 and 194, a glycine-serine insertion at codons 195 and 196, and, recently, an additional mutation at nucleotide 682 (C682A). In this study, sulfisoxazole...
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