Article

Vascular muscle cell phenotype changes in Marfan Syndrome aneurisms driven by Vitamin D and SERCA2 diminutions and Ca 2+ increases

2026-06-05

Abstract excerpt

<title>Abstract</title> <p> Marfan syndrome (MFS) results from heterogeneous mutations in fibrillin-1. This releases TGF-β1 contributing to thoracic aneurysms formation (TAA). Vit D might participate in this process. Here we evaluate whether vit D deficiency and alteration of the SERCA/IP3 axis result in increased Ca <sup>2+</sup> and lead to of vascular smooth muscle cell (VSMC) remodeling. We evaluated Vit D...

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Literature Corpus work: b42a53f7-8461-5682-a588-c1f58a5d9032
DOI: 10.21203/rs.3.rs-9716736/v1

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Vascular muscle cell phenotype changes in Marfan Syndrome aneurisms driven by Vitamin D and SERCA2 diminutions and Ca 2+ increasesDOI 10.21203/rs.3.rs-9716736/v1Read

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