Article
Fibrillin-1 mutation contributes to Marfan syndrome by inhibiting Cav1.2-mediated cell proliferation in vascular smooth muscle cells.
Channels (Austin, Tex.) - 1 Dec 2023
Lin Wenfeng, Xiong Jiaqi, Jiang Yefan, Liu Hao, Bian Jinhui, Wang Juejin, Shao Yongfeng, Ni Buqing
Abstract excerpt
Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder caused by mutation in fibrillin-1 (FBN1). However, the molecular mechanism underlying MFS remains poorly understood. The study aimed to explore how the L-type calcium channel (CaV1.2) modulates disease progression of MFS and to identify a potential effective target for attenuating MFS. KEGG enrichment analysis showed that the calcium...
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