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Article

Calcium promotes vascular smooth muscle cell phenotypic switching in Marfan syndrome.

Biochemical and biophysical research communications - 12 Jul 2023

Yang Yunxiao, Xie Enzehua, Liu Yuhua, Peng Zhan, Yu Cuntao, Hua Kun, Yang Xiubin

Abstract excerpt

Fibrillin 1 (Fbn1) mutations cause Marfan syndrome (MFS), with aortic root dilatation, dissection, and rupture. Few studies reported the blood calcium and lipid profile of MFS, and the effect of vascular smooth muscle cell (VSMC) phenotypic switching on MFS aortic aneurysm is unclear. Here, we aimed to investigate the role of calcium-related VSMC phenotypic switching in MFS. We retrospectively collected MFS...

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PMID: 37156050
DOI: 10.1016/j.bbrc.2023.05.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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