Article

Novel ACE2-IgG1 fusions with improved <i>in vitro</i> and <i>in vivo</i> activity against SARS-CoV2

2020-06-15

Abstract excerpt

SARS-CoV2, the etiologic agent of COVID-19, uses ACE2 as a cell entry receptor. Soluble ACE2 has been shown to have neutralizing antiviral activity but has a short half-life and no active transport mechanism from the circulation into the alveolar spaces of the lung. To overcome this, we constructed an ACE2-human IgG1 fusion protein with mutations in the catalytic domain of ACE2. This fusion protein contained a LAL...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b3fd0d5e-4e34-56db-9378-d136740a9e9d
DOI: 10.1101/2020.06.15.152157

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel ACE2-IgG1 fusions with improved <i>in vitro</i> and <i>in vivo</i> activity against SARS-CoV2DOI 10.1101/2020.06.15.152157Read

ACE2-IgG1 fusions with improved in vitro and in vivo activity against SARS-CoV-2Semantic proximity Read

An engineered ACE2 decoy receptor can be administered by inhalation and potently targets the BA.1 and BA.2 omicron variants of SARS-CoV-2Semantic proximity Read

ACE2-based decoy receptors for SARS coronavirus 2.Semantic proximity Read

Picomolar inhibition of SARS-CoV-2 variants of concern by an engineered ACE2-IgG4-Fc fusion proteinSemantic proximity Read

A Soluble ACE2 Microbody Protein Fused to a Single Immunoglobulin Fc Domain is a Potent Inhibitor of SARS-CoV-2 InfectionSemantic proximity Read

Picomolar inhibition of SARS-CoV-2 variants of concern by an engineered ACE2-IgG4-Fc fusion proteinSemantic proximity Read

ACE2 Nascence, Trafficking and SARS-CoV-2 Pathogenesis: The Saga ContinuesSemantic proximity Read

Inhibition of ACE2‐Spike Interaction by an ACE2 Binder Suppresses SARS‐CoV‐2 EntrySemantic proximity Read

Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activitiesSemantic proximity Read

ACE2 Nascence, trafficking, and SARS-CoV-2 pathogenesis: the saga continues.Semantic proximity Read

ACE2 in the Era of SARS-CoV-2: Controversies and Novel PerspectivesSemantic proximity Read

David versus goliath: ACE2-Fc receptor traps as potential SARS-CoV-2 inhibitorsSemantic proximity Read