Article

Picomolar inhibition of SARS-CoV-2 variants of concern by an engineered ACE2-IgG4-Fc fusion protein

2021-05-14

Abstract excerpt

<title>Abstract</title> <p>SARS-CoV-2 enters host cells after binding through its spike glycoprotein to the angiotensin-converting enzyme 2 (ACE2) receptor. Soluble ACE2 ectodomains bind and neutralize the virus, yet their short in vivo half-live limits their therapeutic use. This limitation can be overcome by fusing the fragment crystallizable (Fc) part of human immunoglobulin G (IgG) to the ACE2 ectodomain, but...

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Literature Corpus work: c25ae7af-9afd-5c81-99e1-d23a00e38345
DOI: 10.21203/rs.3.rs-459941/v1

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