Article

Amplification of Olfactory Signals by Anoctamin 9 is Essential for Mammalian Olfaction: a Risk Factor for the Covid-19-associated Anosmia

2022-03-03

Abstract excerpt

Sensing smells of foods, prey, or predators determines animal survival. Olfactory sensory neurons in the olfactory epithelium (OE) detect odorants, where cAMP and Ca 2+ play a significant role in transducing odorant inputs to electrical activity. Here we show Anoctamin 9, a cation channel activated by cAMP/PKA pathway, is expressed in the OE and amplifies olfactory signals. Ano9 - deficient mice had reduced olfa...

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Literature Corpus work: b3fa6273-77e5-5f80-a37a-5aa811f93cff
DOI: 10.1101/2022.03.02.482745

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