Article
Mutations in olfactory signal transduction genes are not a major cause of human congenital general anosmia.
Chemical senses - 1 Jan 2007
Feldmesser Ester, Bercovich Dani, Avidan Nili, Halbertal Shmuel, Haim Liora, Gross-Isseroff Ruth, Goshen Sivan, Lancet Doron
Abstract excerpt
Anosmia affects the western world population, mostly the elderly, reaching to 5% in subjects over the age of 45 years and strongly lowering their quality of life. A smaller minority (about 0.01%) is born without a sense of smell, afflicted with congenital general anosmia (CGA). No causative genes for human CGA have been identified yet, except for some syndromic cases such as Kallman syndrome. In mice, however,...
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