Article

Interferon receptor gene dosage determines diverse hallmarks of Down syndrome

2022-02-05

Abstract excerpt

Trisomy 21 causes Down syndrome, a condition characterized by cognitive impairments, immune dysregulation, and atypical morphogenesis. Using whole blood transcriptome analysis, we demonstrate that specific overexpression of four interferon receptors encoded on chromosome 21 associates with chronic interferon hyperactivity and systemic inflammation in Down syndrome. To define the contribution of interferon receptor...

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Literature Corpus work: bedaf74b-b61c-5e04-9d67-fe3b55e246a7
DOI: 10.1101/2022.02.03.478982

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