Article

The usage of human IGHJ genes follows a particular nonrandom selection: The recombination signal sequence affects the usage of human IGHJ genes

2019-10-07

Abstract excerpt

<h4>ABSTRACT</h4> The formation of the B cell receptor (BCR) heavy chain variable region is derived from the germline V(D)J gene rearrangement according to the “12/23” rule and the “beyond 12/23” rule. The usage frequency of each V(D)J gene in the peripheral BCR repertoires is related to the initial recombination, self-tolerance selection, and the clonal proliferative response. However, their specific differences...

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Literature Corpus work: b32effa5-efa5-5ac6-8496-9e8d4795aec3
DOI: 10.1101/792085

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