Article

Erythropoietin production in embryonic neural cells is controlled by hypoxia-inducible factors and histone deacetylases in an undifferentiated state

2024-03-02

Abstract excerpt

During mammalian development, production sites of the erythroid growth factor erythropoietin (EPO) shift from the neural tissues to the liver in embryos and to the adult kidneys. Embryonic neural EPO-producing (NEP) cells, a subpopulation of neuroepithelial and neural crest cells, express the Epo gene between embryonic day (E) 8.5 and E11.5 to promote primitive erythropoiesis in mice. While Epo gene expression i...

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Literature Corpus work: b320c6be-c6f6-58d3-a524-d8b5f6423900
DOI: 10.1101/2024.02.28.582479

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