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Article

Qualitative network modeling of the Myc-p53 control system of cell proliferation and differentiation.

Biophysical journal - 2 Nov 2011

Aguda Baltazar D, Kim Yangjin, Kim Hong Sug, Friedman Avner, Fine Howard A

Abstract excerpt

A kinetic model of a molecular control system for the cellular decision to proliferate or differentiate is formulated and analyzed for the purpose of understanding how the system can break down in cancer cells. The proposed core of this control system is composed of the transcription factors Myc and p53. The network of interactions between these factors involves negative and positive feedback loops that are...

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Source

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Identifiers

PMID: 22067145
DOI: 10.1016/j.bpj.2011.09.052
PMCID: PMC3207173

Genes

MDM2
PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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