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Article

Nirmatrelvir Resistant SARS-CoV-2 Variants with High Fitness in Vitro

2022-06-07

Abstract excerpt

The oral protease inhibitor nirmatrelvir is expected to play a pivotal role for prevention of severe cases of coronavirus disease 2019 (COVID-19). To facilitate monitoring of potentially emerging resistance, we studied severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from nirmatrelvir. Resistant variants selected in cell culture harbored different combinations of substitutions in the SARS-CoV-2...

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Literature Corpus work
b2039cbf-35b6-5fb5-a48c-d39c63681db1
DOI
10.1101/2022.06.06.494921
Open publication

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Nirmatrelvir Resistant SARS-CoV-2 Variants with High Fitness in VitroDOI 10.1101/2022.06.06.494921
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