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Nirmatrelvir-resistant SARS-CoV-2 variants with high fitness in an infectious cell culture system

21 Dec 2022

Abstract excerpt

The oral protease inhibitor nirmatrelvir is of key importance for prevention of severe coronavirus disease 2019 (COVID-19). To facilitate resistance monitoring, we studied severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from nirmatrelvir in cell culture. Resistant variants harbored combinations of substitutions in the SARS-CoV-2 main protease (Mpro). Reverse genetics revealed that E166V and...

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PMID: 36542720
DOI: 10.1126/sciadv.add7197

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