Article

Modi-2, a vaccine stimulating CD4 mediated responses to homocitrullinated self-epitopes, as a therapy for solid cancers

2024-04-30

Abstract excerpt

<title>Abstract</title> <p>Stresses within the tumour microenvironment can mediate post-translational modifications (PTM) of self-proteins. Homocitrullination is the conversion of lysine residues to homocitrulline which can generate neoepitopes and bypass self-tolerance. In this study a vaccine targeting homocitrullinated peptide antigens was assessed for its ability to stimulate anti-tumour immunity. Peptides th...

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Literature Corpus work: b1aa0d29-5476-5210-9143-a9176a492d94
DOI: 10.21203/rs.3.rs-4207368/v1

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