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Perturbing LSD1 and WNT rewires transcription to synergistically induce AML differentiation

16 Apr 2025

Abstract excerpt

Abstract Impaired differentiation is a hallmark of myeloid malignancies1,2. Therapies that enable cells to circumvent the differentiation block, such as all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), are by and large curative in acute promyelocytic leukaemia3, but whether ‘differentiation therapy’ is a generalizable therapeutic approach for acute myeloid leukaemia (AML) and beyond remains incompletely...

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PMID: 40240608
DOI: 10.1038/s41586-025-08915-1

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