Article

GenSLMs: Genome-scale language models reveal SARS-CoV-2 evolutionary dynamics

2023-10-27

Abstract excerpt

We seek to transform how new and emergent variants of pandemic-causing viruses, specifically SARS-CoV-2, are identified and classified. By adapting large language models (LLMs) for genomic data, we build genome-scale language models (GenSLMs) which can learn the evolutionary landscape of SARS-CoV-2 genomes. By pre-training on over 110 million prokaryotic gene sequences and fine-tuning a SARS-CoV-2-specific model o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b0d158cc-479c-55e0-bb4a-c570c831a559
DOI: 10.1177/10943420231201154

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GenSLMs: Genome-scale language models reveal SARS-CoV-2 evolutionary dynamicsDOI 10.1177/10943420231201154Read

A deep mutational scanning-informed protein language model predicts SARS-CoV-2 evolution dynamics with spatiotemporal resolution.Semantic proximity Read

From single-sequences to evolutionary trajectories: protein language models capture the evolutionary potential of SARS-CoV-2.Semantic proximity Read

Generative prediction of real-world prevalent SARS-CoV-2 mutation with in silico virus evolutionSemantic proximity Read

Running ahead of evolution—AI-based simulation for predicting future high-risk SARS-CoV-2 variantsSemantic proximity Read

A predictive language model for SARS-CoV-2 evolution.Semantic proximity Read

Fine-Tuning Protein Language Models Unlocks the Potential of Underrepresented Viral ProteomesSemantic proximity Read

SARITA: a large language model for generating the S1 subunit of the SARS-CoV-2 spike protein.Semantic proximity Read

HViLM: A Foundation Model for Viral Genomics Enables Multi-Task Prediction of Pathogenicity, Transmissibility, and Host TropismSemantic proximity Read

SARITA: A Large Language Model for Generating the S1 Subunit of the SARS-CoV-2 Spike ProteinSemantic proximity Read

Running ahead of evolution - AI based simulation for predicting future high-risk SARS-CoV-2 variantsSemantic proximity Read

Genomic Surveillance of COVID-19 Variants with Language Models and Machine LearningSemantic proximity Read

Genomic Touchstone: Benchmarking Genomic Language Models in the Context of the Central DogmaSemantic proximity Read