Article
Genetic modification of the AJCC classification of papillary thyroid cancer: an international, multicentre, retrospective cohort study.
The Lancet. Oncology - 1 Oct 2025
Xing Mingzhao, Lin Shuhuang, Mathur Aarti, Li Ying, Bendlova Bela, Kuklikova Vlasta, Melo Miguel, Jesus Tito Teles, Soares Paula, Colombo Carla, Fugazzola Laura, Mitsutake Norisato, Matsuse Michiko, Sako Ayaka, Estrada-Florez Ana Patricia, Carvajal-Carmona Luis G, Bohórquez Mabel E, Mian Caterina, Vianello Federica, O'Neill Christine J, Clifton-Bligh Roderick, Czarniecka Agnieszka, Jarzab Barbara, Jung Chan Kwon, Brahma Bayu, Ladenson Paul W, Park Young Joo
Abstract excerpt
BACKGROUND: The four-stage American Joint Committee on Cancer (AJCC) staging system has been used for almost 50 years for assessing the risk of multiple cancers; the AJCC classification for papillary thyroid cancer is solely based on clinical parameters, and despite updated editions its accuracy remains suboptimal. We aimed to evaluate whether the performance of the AJCC system could be improved by integrating...
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