Article

DNA methylation changes and increased mRNA expression of coagulation proteins, Factor V and Thrombomodulin in Fuchs endothelial corneal dystrophy

2022-12-13

Abstract excerpt

<title>Abstract</title> <p> Late-onset Fuchs endothelial corneal dystrophy (FECD) is a disease affecting the corneal endothelium (CE), associated with a cytosine-thymine-guanine repeat expansion at the CTG18.1 locus in the transcription factor 4 ( <italic>TCF4</italic> ) gene. It is unknown if CTG18.1 expansions affect global methylation including <italic>TCF4</italic> gene in CE, or if global CE methylation...

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Literature Corpus work: b03a02fd-f832-5d96-97bd-a12cc4e358fd
DOI: 10.21203/rs.3.rs-1758860/v2

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