Article

Transcription factors involved in stem cell maintenance are downstream of Slug/Snail2 and repressed by TGF-β in bronchial basal stem/progenitor cells from COPD

2020-01-18

Abstract excerpt

Patients with COPD have many anomalies in their airway epithelium, and their basal stem/progenitor cells show a decrease in self-renewal and differentiation potential. The objective of this study was to identify deregulations in the genetic program of COPD bronchial basal stem/progenitor cells that could account for their exhaustion. TGF-β is found at higher levels in the lungs of COPD subjects. It has been shown...

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Literature Corpus work: b02b7e9e-a80e-5d0d-8cb6-fdd94b13ba93
DOI: 10.1101/2020.01.17.910406

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