Article

Transcription factors involved in stem cell maintenance are downstream of Slug/Snail2 and repressed by TGF-β in bronchial epithelial progenitors from Chronic Obstructive Pulmonary Disease

2019-08-13

Abstract excerpt

<title>Abstract</title> <p>Objectives: Patients with Chronic Obstructive Pulmonary Disease (COPD) have a bronchial epithelium with many anomalies and basal/progenitor cells showing a decrease of self-renewal and differentiation potential. The objective of this study was to identify deregulations in the genetic program of COPD bronchial progenitors that could account for their exhaustion. The transcription factor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3ecb8e24-0843-5841-839d-9e3fd7fa6326
DOI: 10.21203/rs.2.12678/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcription factors involved in stem cell maintenance are downstream of Slug/Snail2 and repressed by TGF-β in bronchial epithelial progenitors from Chronic Obstructive Pulmonary DiseaseDOI 10.21203/rs.2.12678/v1Read

Transcription factors involved in stem cell maintenance are downstream of Slug/Snail2 and repressed by TGF-β in bronchial basal stem/progenitor cells from COPDSemantic proximity Read

Proliferation genes repressed by TGF-β are downstream of Slug/Snail2 in normal bronchial epithelial progenitors and are deregulated in COPDSemantic proximity Read

Transforming growth factor-β1 as a biomarker in COPD patients with pulmonary fibrosisSemantic proximity Read

TGF-beta signaling in COPD: deciphering genetic and cellular susceptibilities for future therapeutic regimen.Semantic proximity Read

Isolation of stem/progenitor cells from normal lung tissue of adult humansSemantic proximity Read

Epigenetic deregulation of IFN and WNT pathways in AT2 cells impairs alveolar regeneration (in COPD)Semantic proximity Read

Exaggerated BMP4 signalling alters human airway basal progenitor cell differentiation to cigarette smoking-related phenotypesSemantic proximity Read

TGF-β induced EMT and stemness characteristics are associated with epigenetic regulation in lung cancerSemantic proximity Read

Effects of smoking on the tissue regeneration-associated functions of human endometrial stem cells via a novel target gene SERPINB2Semantic proximity Read

Up-regulation of Notch signaling and cell-differentiation inhibitory transcription factors in the lower airways of stable COPD patientsSemantic proximity Read

Hedgehog pathway and its inhibitors in chronic obstructive pulmonary disease (COPD).Semantic proximity Read

p53 regulation by MDM2 contributes to self‐renewal and differentiation of basal stem cells in mouse and human airway epitheliumSemantic proximity Read