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Article

Satellite cell senescence underlies myopathy in a mouse model of limb-girdle muscular dystrophy 2H

16 Apr 2012

Abstract excerpt

Mutations in the E3 ubiquitin ligase tripartite motif-containing 32 (TRIM32) are responsible for the disease limb-girdle muscular dystrophy 2H (LGMD2H). Previously, we generated Trim32 knockout mice (Trim32-/- mice) and showed that they display a myopathic phenotype accompanied by neurogenic features. Here, we used these mice to investigate the muscle-specific defects arising from the absence of TRIM32, which...

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PMID: 22505452
DOI: 10.1172/jci59581

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