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Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight

11 Jun 2024

Abstract excerpt

Microgravity is associated with immunological dysfunction, though the mechanisms are poorly understood. Here, using single-cell analysis of human peripheral blood mononuclear cells (PBMCs) exposed to short term (25 hours) simulated microgravity, we characterize altered genes and pathways at basal and stimulated states with a Toll-like Receptor-7/8 agonist. We validate single-cell analysis by RNA sequencing and...

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PMID: 38862487
DOI: 10.1038/s41467-023-42013-y

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