Article

A progeria-associated BAF-1 mutation modulates gene expression and accelerates aging in <i>C. elegans</i>

2024-03-17

Abstract excerpt

Alterations in the nuclear envelope are linked to a variety of rare diseases termed laminopathies. These include both tissue specific and systemic diseases. A single amino acid substitution in human barrier to autointegration factor (BAF) at position 12 (A12T) causes Nestor-Guillermo Progeria Syndrome (NGPS). This premature ageing condition affects a variety of tissues, leading to growth retardation and severe ske...

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Literature Corpus work: afce60b9-ad8a-569b-ba3d-769940c1c360
DOI: 10.1101/2024.03.17.585430

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