Functional Mapping of the <i>Trypanosoma cruzi</i> Serinome by Fluorophosphonate Activity-Based Protein Profiling

Abstract excerpt

Serine hydrolases (SHs) constitute one of the largest enzyme superfamilies in eukaryotes, yet their roles in Trypanosoma cruzi, the causative agent of Chagas disease, remain largely uncharacterized. Here, we report an activity-based chemoproteomic map of the T. cruzi epimastigote serinome by combining genome-informed in silico curation with whole-cell activity-based protein profiling (ABPP) using a panel of cel...

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• Catalytic Domain
• Cytosol
• HIV/AIDS drug development and treatment
• HIV Research and Treatment
• Hydrolysis
• Phosphatidylcholines
• Phospholipases A
• Trypanosoma species research and implications

Identifiers and source

Literature Corpus work

afb20b0d-bc87-5d3c-9b32-c1efaaf3bfaa

DOI

10.64898/2026.07.18.739127