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Dual-purpose isocyanides produced by <i>Aspergillus fumigatus</i> contribute to cellular copper sufficiency and exhibit antimicrobial activity

2020-07-24

Abstract excerpt

The maintenance of sufficient but non-toxic pools of metal micronutrients is accomplished through diverse homeostasis mechanisms in fungi. Siderophores play a well-established role for iron homeostasis; however, no copper-binding analogs have been found in fungi. Here we demonstrate that in Aspergillus fumigatus isocyanides derived from the xan biosynthetic gene cluster (BGC) bind copper, impact cellular copper...

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Identifiers and source

Literature Corpus work
aeb93408-fc9a-5c0b-950b-1e4eb50662f0
DOI
10.1101/2020.07.23.217810
Open publication

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Dual-purpose isocyanides produced by <i>Aspergillus fumigatus</i> contribute to cellular copper sufficiency and exhibit antimicrobial activityDOI 10.1101/2020.07.23.217810
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