Article
Dual-purpose isocyanides produced by Aspergillus fumigatus contribute to cellular copper sufficiency and exhibit antimicrobial activity.
Proceedings of the National Academy of Sciences of the United States of America - 23 Feb 2021
Raffa Nicholas, Won Tae Hyung, Sukowaty Andrew, Candor Kathleen, Cui Chengsen, Halder Saayak, Dai Mingji, Landero-Figueroa Julio A, Schroeder Frank C, Keller Nancy P
Abstract excerpt
The maintenance of sufficient but nontoxic pools of metal micronutrients is accomplished through diverse homeostasis mechanisms in fungi. Siderophores play a well established role for iron homeostasis; however, no copper-binding analogs have been found in fungi. Here we demonstrate that, in Aspergillus fumigatus, xanthocillin and other isocyanides derived from the xan biosynthetic gene cluster (BGC) bind copper,...
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