Article

Myoscaffolds reveal laminin scarring is detrimental for stem cell function while sarcospan induces compensatory fibrosis

2022-07-07

Abstract excerpt

<h4>ABSTRACT</h4> We developed an on-slide decellularization approach to generate acellular extracellular matrix (ECM) scaffolds that can be repopulated with various cell types to interrogate cell-ECM interactions. Using this platform, we investigated whether fibrotic ECM scarring affected human skeletal muscle progenitor cell (SMPC) functions that are essential for myoregeneration. SMPCs exhibited robust adhesio...

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Literature Corpus work: ae47e805-5bdb-570c-84b9-0bb8af5b036f
DOI: 10.1101/2022.07.07.497559

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