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Article

Multiancestry Genome-Wide Association Study of Early Childhood Caries.

Journal of dental research - 1 Mar 2025

Shrestha P, Graff M, Gu Y, Wang Y, Avery C L, Ginnis J, Simancas-Pallares M A, Ferreira Zandoná A G, Alotaibi R N, Orlova E, Ahn H S, Nguyen K N, Highland H M, Lin D Y, Preisser J S, Slade G D, Marazita M L, North K E, Divaris K

Abstract excerpt

Early childhood caries (ECC) is the most common noncommunicable childhood disease-an important health problem with known environmental and social/behavioral influences lacking consensus genetic risk loci. To address this knowledge gap, we conducted a genome-wide association study of ECC in a multiancestry population of U.S. preschool-age children (N = 6,103) ages 3 to 5 y participating in a community-based...

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Identifiers

PMID: 39698793
DOI: 10.1177/00220345241291528
PMCID: PMC11843792

Genes

DLGAP1
PITX1
SLC41A3
TAAR6

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