Article

Translating GWAS-identified loci for cardiac rhythm and rate using an <i>in vivo</i> image- and CRISPR/Cas9-based approach

2018-08-09

Abstract excerpt

A meta-analysis of genome-wide association studies (GWAS) identified eight loci that are associated with heart rate variability (HRV), but candidate genes in these loci remain uncharacterized. We developed an image- and CRISPR/Cas9-based pipeline to systematically characterize candidate genes for HRV in live zebrafish embryos. Nine zebrafish orthologues of six human candidate genes were targeted simultaneously in...

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Literature Corpus work: ae107ec0-f48b-541c-9bf6-7a080f64f8d8
DOI: 10.1101/385500

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