Article

Endothelial cell-derived, secreted long non-coding RNAs <i>Gadlor1</i> and <i>Gadlor2</i> aggravate pathological cardiac remodeling via intercellular crosstalk

2022-09-19

Abstract excerpt

<h4>Background</h4> Pathological overload triggers maladaptive myocardial remodeling that leads to heart failure. Recent studies have shown that long non-coding RNAs (lncRNAs) regulate cardiac remodeling. This study investigates two recently discovered, secreted lncRNAs, Gadlor1 and Gadlor2 ( Gadlor 1/2 ). <h4>Methods</h4> We generated compound Gadlor 1/2 knock-out (KO) mice and compared their response to p...

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Literature Corpus work: ad56fe0b-60bb-526a-9bfd-54dda07f5ef1
DOI: 10.1101/2022.09.19.508486

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Endothelial cell-derived, secreted long non-coding RNAs <i>Gadlor1</i> and <i>Gadlor2</i> aggravate pathological cardiac remodeling via intercellular crosstalkDOI 10.1101/2022.09.19.508486Read

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