Article
Identification of cardiac long non-coding RNA profile in human dilated cardiomyopathy.
Cardiovascular research - 1 Apr 2018
Li Huaping, Chen Chen, Fan Jiahui, Yin Zhongwei, Ni Li, Cianflone Katherine, Wang Yan, Wang Dao Wen
Abstract excerpt
Aims: Dilated cardiomyopathy (DCM) induced chronic heart failure is a life-threatening disease worldwide. Long non-coding RNAs (lncRNAs) are potential new therapeutic targets and may provide new pathophysiological mechanisms for development of DCM. Methods and results: Microarray assays in 14 DCM and 10 control human heart samples identified 313 significantly differentially expressed lncRNAs. SiRNAs were used to...
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