Article

TMEM147 aggravates the progression of HCC by modulating cholesterol homeostasis, suppressing ferroptosis, and promoting M2 polarization of TAMs

2023-05-22

Abstract excerpt

<h4>Background: </h4> The endoplasmic reticulum (ER) regulates critical processes, including lipid synthesis, which can be affected by transmembrane proteins localized in the ER membrane. One of them, the transmembrane protein 147 (TMEM147) has been recently implicated for its role in hepatocellular carcinoma (HCC) tumorigenesis, though the mechanisms remain unclear. Here, we investigated the role of TMEM147 in HC...

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Literature Corpus work: ac6d5799-5896-5489-bd44-48a27e7793ea
DOI: 10.21203/rs.3.rs-2955183/v1

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