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Article

Interpretation of skeletal variations for human risk assessment: delayed ossification and wavy ribs

1 Dec 2007

Abstract excerpt

Delayed (or incomplete) ossification of developing fetal bones and wavy ribs are some of the most common skeletal variations encountered in regulatory guideline developmental toxicity studies. Although they tend to be regarded as minor effects, they can be quite sensitive and consequently may influence the study lowest-observed-adverse-effect levels (LOAELs), and thus, impact classification, labeling, and risk...

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PMID: 18157903
DOI: 10.1002/bdrb.20133

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