Article
Medical genetics: 1. Clinical teratology in the age of genomics.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne - 6 Aug 2002
Polifka Janine E, Friedman J M
Abstract excerpt
Teratogenic exposures are those that can cause an embryo or fetus to develop abnormally. Several factors determine whether an agent is teratogenic, including the gestational timing of the exposure, as well as the dose, route and nature of the agent itself. We review the general concepts of teratogenesis, as well as known genetic susceptibilities to teratogenic effects, with a special focus on antiepileptic drugs....
Topics
- Adult
- Alcohol Drinking
- Anticonvulsants
- Environmental Exposure
- Epilepsy
- Female
- Genetic Counseling
- Genetic Predisposition to Disease
- Genetic Testing
- Genetics, Medical
- Humans
- Pregnancy
- Risk Assessment
- Smoking
- Teratogens
- Valproic Acid
